ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Triethylamine → 2-Methylpentane

HRID 1183027
ノート
印刷プレビュー

反応式

HRID 1183027 の反応式
Cl.[NH2:2][C@@H:3]([CH2:17][CH2:18][CH3:19])[CH2:4][NH:5][C:6]([C:8]1[C:13]([NH2:14])=[N:12][C:11]([NH2:15])=[C:10]([Cl:16])[N:9]=1)=[O:7].C(N(CC)CC)C.[C:27]([O:31][C:32](=[O:59])[N:33](/[C:45](=[N:51]/[C:52]([O:54][C:55]([CH3:58])([CH3:57])[CH3:56])=[O:53])/N1C=CC=N1)[CH2:34][CH2:35][CH2:36][C:37]1[CH:42]=[CH:41][C:40]([O:43][CH3:44])=[CH:39][CH:38]=1)([CH3:30])([CH3:29])[CH3:28].CCOC(C)=O>CN(C=O)C.O>[CH3:34][CH2:35][CH2:36][CH:37]([CH3:42])[CH3:38].[NH2:14][C:13]1[C:8]([C:6](=[O:7])[NH:5][CH2:4][C@H:3]([CH2:17][CH2:18][CH3:19])[NH:2]/[C:45](=[N:51]\[C:52](=[O:53])[O:54][C:55]([CH3:58])([CH3:57])[CH3:56])/[N:33]([CH2:34][CH2:35][CH2:36][C:37]2[CH:38]=[CH:39][C:40]([O:43][CH3:44])=[CH:41][CH:42]=2)[C:32](=[O:59])[O:31][C:27]([CH3:28])([CH3:30])[CH3:29])=[N:9][C:10]([Cl:16])=[C:11]([NH2:15])[N:12]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

8

反応物 4

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 866518883,5-Diamino-6-chloro-pyrazine-2-carboxylic acid ((S)-2-amino-pentyl)-amide hydrochlorideHCID 87204231tert-butyl N-[3-(4-methoxyphenyl)propyl]-N-[(Z)-N-[(2-methylpropan-2-yl)oxycarbonyl]-C-pyrazol-1-ylcarbonimidoyl]carbamate2 回

生成物 2

HCID 78922-Methylpentane
HCID 178448282
HCID 178448282、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

To a stirred solution of 3,5-Diamino-6-chloro-pyrazine-2-carboxylic acid ((S)-2-amino-pentyl)-amide hydrochloride (Example 4) (0.2 g, 0.73 mmol) in DMF (3 mL) is added triethylamine (0.22 mL, 1.54 mmol) followed by {[(Z)-tert-Butoxycarbonylimino]-pyrazol-1-yl-methyl}-[3-(4-methoxy-phenyl)-propyl]-carbamic acid tert-butyl ester (Intermediate E) and the resulting deep yellow solution is stirred at RT for 3 days. The reaction mixture is diluted with water (50 mL) and extracted with EtOAc (100 mL). The organic phase is washed with water (50 ml), dried (MgSO4), and the solvent removed in vacuo to afford a yellow oil. Chromatography (SiO2, EtOAc:iso-hexane, gradient 0-100%) affords (S,E)-tert-butyl 1-(3,5-diamino-6-chloropyrazin-2-yl)-7-(3-(4-methoxyphenyl)propyl)-10,10-dimethyl-1,8-dioxo-4-propyl-9-oxa-2,5,7-triazaundecan-6-ylidenecarbamate as a colourless oil. [M+H]+ 663.

後処理

  1. extractionextracted with EtOAc (100 mL)
  2. washThe organic phase is washed with water (50 ml)
  3. dry with materialdried (MgSO4)
  4. customthe solvent removed in vacuo
  5. customto afford a yellow oil

出典と根拠

ORDレコード
ord-145f8ae9c7254d80ae745ec4628b8ab5
出典データセット
uspto-grants-2014_03
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08664228B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート