Sulfuryl chloride → HCID 67361928、化合物
反応式
[CH3:1][O:2][C:3]([C:5]1[CH:9]=[C:8]([O:10][CH3:11])[N:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])[N:6]=1)=[O:4].S(Cl)([Cl:22])(=O)=O>C(O)(=O)C>[CH3:1][O:2][C:3]([C:5]1[C:9]([Cl:22])=[C:8]([O:10][CH3:11])[N:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[F:18])[N:6]=1)=[O:4]参加物
4
実験手順
300 mg (1.2 mmol) of 1-(2-fluoro-phenyl)-5-methoxy-1H-pyrazole-3-carboxylic acid methyl ester was dissolved in 3 ml of acetic acid. 162 mg (1.2 mmol) of sulfuryl chloride were added and the mixture stirred for 4 h at room temperature. The solvent was removed in vacuo and the residue subjected to acidic aqueous work-up. The obtained crude title compound (330 mg) was used in the hydrolysis step without further purification.
後処理
- customThe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-11566f3b6b4e45a6bc447bc95b335b16
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08664257B2
反応ノート
読み込み中…