Lithium borohydride → [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol
反応式
C[O:2][C:3]([C:5]1[C:6]([CH3:17])=[N:7][O:8][C:9]=1[C:10]1[CH:15]=[CH:14][C:13]([Br:16])=[CH:12][CH:11]=1)=O.[BH4-].[Li+]>CCO>[Br:16][C:13]1[CH:12]=[CH:11][C:10]([C:9]2[O:8][N:7]=[C:6]([CH3:17])[C:5]=2[CH2:3][OH:2])=[CH:15][CH:14]=1参加物
4
反応条件
- 温度
- 60 °C
実験手順
5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid methyl ester (5 g, 16.8 mmol) and lithium borohydride (1.85 g, 84.1 mmol) were combined in EtOH and stirred at 60° C. After aqueous workup, the crude material was purified by silica gel chromatography to give the title compound.
後処理
- customAfter aqueous workup, the crude material was purified by silica gel chromatography
出典と根拠
- ORDレコード
- ord-f1f87bf6c65f4fedbc6ff09c4e4ae778
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08664220B2
反応ノート
読み込み中…