Ammonia → tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione

反応式

[CH:1]1([C:11]([O:13]CC)=O)[CH2:5][CH2:4][CH2:3][CH:2]1[C:6](OCC)=[O:7].[NH3:16]>>[C:6]1(=[O:7])[CH:2]2[CH2:3][CH2:4][CH2:5][CH:1]2[C:11](=[O:13])[NH:16]1

参加物

反応物 2

HCID 222Ammonia

HCID 3021700Diethyl cyclopentane-1,2-dicarboxylate

生成物 1

HCID 110709tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione収率 96%

反応条件

温度: 130 °C

実験手順

Load 1 kg of diethyl 1,2-cyclopentanedicarboxylate and 1.02 kg of 27% ammonia into an autoclave. The reaction mixture is heated in the autoclave at a temperature of 130° C. for a minimum of 4 hours. After cooling to 60° C. and depressurisation, evaporation of the solvent is carried out. The residue is then subjected to pyrolysis at 280° C. for 1 hour. The imide is purified by distillation in vacuo (4-12 mbars) at a temperature of 200° C. After isolation, the title product is obtained in a yield of 96%.

後処理

temperatureAfter cooling to 60° C.
customdepressurisation, evaporation of the solvent
distillationThe imide is purified by distillation in vacuo (4-12 mbars) at a temperature of 200° C

出典と根拠

ORDレコード: ord-4a96273e15254919994c22d722200980
出典データセット: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08664408B2

反応ノート

読み込み中…

参加物