3,4-Dihydro-8-fluoro-2H-1,4-benzoxazine-2-carboxamide → Dihydro-8-chloro-2H-1,4-benzoxazine-2-carboxamide

反応式

F[C:2]1[C:11]2[O:10][CH:9]([C:12]([NH2:14])=[O:13])[CH2:8][NH:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[Cl:15]C1C2OCCNC=2C=CC=1.CCC([O-])=O>>[Cl:15][C:2]1[C:11]2[O:10][CH:9]([C:12]([NH2:14])=[O:13])[CH2:8][NH:7][C:6]=2[CH:5]=[CH:4][CH:3]=1

参加物

反応物 2

HCID 674804863,4-Dihydro-8-fluoro-2H-1,4-benzoxazine-2-carboxamide

HCID 866648023,4-dihydro-8-chloro-2H-1,4-benzoxazine 2-ethyl carboxylate

生成物 1

HCID 67496535Dihydro-8-chloro-2H-1,4-benzoxazine-2-carboxamide

実験手順

This compound is obtained using the same experimental conditions as those used for the synthesis of intermediate 4b but replacing 3,4-dihydro-8-fluoro-2H-1,4-benzoxazine-2-ethyl carboxylate (5b) with 3,4-dihydro-8-chloro-2H-1,4-benzoxazine-2-ethyl carboxylate (5d), [73268-47-0]. The title compound of formula (4d) is obtained.

後処理

customThis compound is obtained

出典と根拠

ORDレコード: ord-9615b7b68524456eb0663878717bdd00
出典データセット: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08669250B2

反応ノート

読み込み中…

参加物