Ethylamine hydrochloride → N-Ethyl-4-(4-((2-methyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)methyl)piperidin-1-yl)benzamide
反応式
[CH3:1][CH:2]1[O:7][C:6]2[CH:8]=[CH:9][C:10]([CH2:12][CH:13]3[CH2:18][CH2:17][N:16]([C:19]4[CH:29]=[CH:28][C:22]([C:23](OCC)=[O:24])=[CH:21][CH:20]=4)[CH2:15][CH2:14]3)=[CH:11][C:5]=2[NH:4][C:3]1=[O:30].Cl.[CH2:32]([NH2:34])[CH3:33]>>[CH2:32]([NH:34][C:23](=[O:24])[C:22]1[CH:21]=[CH:20][C:19]([N:16]2[CH2:15][CH2:14][CH:13]([CH2:12][C:10]3[CH:9]=[CH:8][C:6]4[O:7][CH:2]([CH3:1])[C:3](=[O:30])[NH:4][C:5]=4[CH:11]=3)[CH2:18][CH2:17]2)=[CH:29][CH:28]=1)[CH3:33]参加物
3
実験手順
Saponification of 390D was performed using the general procedure for hydrolysis of carboxylic esters. The resulting carboxylic acid and ethylamine hydrochloride were used in the general procedure for coupling an amine to a carboxylic acid to give the title compound as a pinkish, tan solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.09 (t, J=7.20 Hz, 3H) 1.13-1.31 (m, 2H) 1.40 (d, J=6.82 Hz, 3H) 1.56-1.72 (m, 3H) 2.44 (d, J=6.82 Hz, 2H) 2.62-2.78 (m, 2H) 3.17-3.29 (m, 2H) 3.76-3.89 (m, 2 H) 4.61 (q, J=6.82 Hz, 1H) 6.63-6.78 (m, 2H) 6.88 (dd, J=15.41, 8.59 Hz, 3H) 7.68 (d, J=9.09 Hz, 2H) 8.13 (t, J=5.43 Hz, 1H) 10.59 (s, 1H). ESI-MS: m/z 408.4 (M+H)+.