6-Chloro-2-methylpyridine-3-boronic acid → 4-[5-(6-Chloro-2-methyl-pyridin-3-yl)-2,3-dihydro-benzofuran-2-yl]-piperidine-1-carboxylic acid isopropyl ester

HRID 1184700ノート

反応式

HRID 1184700 の反応式
[CH:1]([O:4][C:5]([N:7]1[CH2:12][CH2:11][CH:10]([CH:13]2[CH2:17][C:16]3[CH:18]=[C:19](Br)[CH:20]=[CH:21][C:15]=3[O:14]2)[CH2:9][CH2:8]1)=[O:6])([CH3:3])[CH3:2].[Cl:23][C:24]1[N:29]=[C:28]([CH3:30])[C:27](B(O)O)=[CH:26][CH:25]=1>>[CH:1]([O:4][C:5]([N:7]1[CH2:12][CH2:11][CH:10]([CH:13]2[CH2:17][C:16]3[CH:18]=[C:19]([C:27]4[C:28]([CH3:30])=[N:29][C:24]([Cl:23])=[CH:25][CH:26]=4)[CH:20]=[CH:21][C:15]=3[O:14]2)[CH2:9][CH2:8]1)=[O:6])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 441191526-Chloro-2-methylpyridine-3-boronic acidHCID 679732624-(5-Bromo-2,3-dihydro-benzofuran-2-yl)-piperidine-1-carboxylic acid isopropyl ester

生成物 1

HCID 866748904-[5-(6-Chloro-2-methyl-pyridin-3-yl)-2,3-dihydro-benzofuran-2-yl]-piperidine-1-carboxylic acid isopropyl ester

実験手順

The title compound is prepared from 4-(5-bromo-2,3-dihydro-benzofuran-2-yl)-piperidine-1-carboxylic acid isopropyl ester and 6-chloro-2-methylpyridine-3-boronic acid following a procedure analogous to that described for Intermediate 15. LC (method 6): tR=1.41 min; Mass spectrum (ESI+): m/z=415 [M+H]+.

出典と根拠

ORDレコード
ord-e9599cfa52c4454d80289dea129aabfb
出典データセット
uspto-grants-2014_03
特許番号
US08669271B2

反応ノート

読み込み中…