Potassium Hydroxide → 7-Amino-2-(furan-2-yl)thieno[2,3-b]pyrazine-6-carboxylic acid

HRID 1184869ノート

反応式

HRID 1184869 の反応式
[NH2:1][C:2]1[C:10]2[C:5](=[N:6][CH:7]=[C:8]([C:11]3[O:12][CH:13]=[CH:14][CH:15]=3)[N:9]=2)[S:4][C:3]=1[C:16]([O:18]CC)=[O:17].[OH-].[K+]>C(O)C.O>[NH2:1][C:2]1[C:10]2[C:5](=[N:6][CH:7]=[C:8]([C:11]3[O:12][CH:13]=[CH:14][CH:15]=3)[N:9]=2)[S:4][C:3]=1[C:16]([OH:18])=[O:17]

参加物

5

反応物 2

HCID 14797Potassium HydroxideHCID 67125677Ethyl 7-amino-2-(furan-2-yl)thieno[2,3-b]pyrazine-6-carboxylate

生成物 1

HCID 671256527-Amino-2-(furan-2-yl)thieno[2,3-b]pyrazine-6-carboxylic acid

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

反応条件

温度
70 °C

実験手順

A suspension of ethyl 7-amino-2-(furan-2-yl)thieno[2,3-b]pyrazine-6-carboxylate 58 (100 mg, 0.346 mmol) and potassium hydroxide (97 mg, 1.728 mmol) in ethanol (5 mL) and water (1 mL) was stirred at 70° C. for 1 h. Quenched in ice cold citric acid solution. The resulting precipitate was collected, washed with water and dried to 7-amino-2-(furan-2-yl)thieno[2,3-b]pyrazine-6-carboxylic acid 59 (66 mg, 73.1%). (m/z)=262 (M+H)+.

後処理

  1. customQuenched in ice cold citric acid solution
  2. customThe resulting precipitate was collected
  3. washwashed with water
  4. dry with materialdried to 7-amino-2-(furan-2-yl)thieno[2,3-b]pyrazine-6-carboxylic acid 59 (66 mg, 73.1%)

出典と根拠

ORDレコード
ord-de422179feba424db090c1d78d440067
出典データセット
uspto-grants-2014_03
特許番号
US08669256B2

反応ノート

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