Hydrochloric Acid → Ethyl 2-(furan-2-yl)quinoline-4-carboxylate

HRID 1185438ノート

反応式

HRID 1185438 の反応式
Cl.[O:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]1[CH:16]=[C:15]([C:17]([OH:19])=[O:18])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=1.[C:20]1(C)C=CC=C[CH:21]=1>C(O)C>[CH2:20]([O:18][C:17]([C:15]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([C:3]2[O:2][CH:6]=[CH:5][CH:4]=2)[CH:16]=1)=[O:19])[CH3:21]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 6976402-(Furan-2-yl)quinoline-4-carboxylic acid

生成物 1

HCID 27000068Ethyl 2-(furan-2-yl)quinoline-4-carboxylate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To 40 ml of a saturated solution of hydrochloric acid in ethanol 2 g of 2-Furan-2-yl-quinoline-4-carboxylic acid was added and the mixture was heated to reflux for 3 h. Then, after cooling to RT, 30 ml of toluene was added and the solvents were removed under reduced pressure. The obtained crude product was pure enough for the next reaction step. Yield: 2.5 g.

後処理

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 3 h
  3. customthe solvents were removed under reduced pressure
  4. customThe obtained crude product
  5. customwas pure enough for the next reaction step

出典と根拠

ORDレコード
ord-d5671b8c2b414fc28a2b84e0a9f1bd62
出典データセット
uspto-grants-2014_03
特許番号
US08669266B2

反応ノート

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