HCID 68599078、化合物 → 4-Carboxymethoxy-7-methyl-quinoline-2-carboxylic acid methyl ester
反応式
[CH3:1][O:2][C:3]([C:5]1[CH:14]=[C:13]([O:15][CH2:16][C:17]([O:19]CC2C=CC=CC=2)=[O:18])[C:12]2[C:7](=[CH:8][C:9]([CH3:27])=[CH:10][CH:11]=2)[N:6]=1)=[O:4]>C(O)C>[CH3:1][O:2][C:3]([C:5]1[CH:14]=[C:13]([O:15][CH2:16][C:17]([OH:19])=[O:18])[C:12]2[C:7](=[CH:8][C:9]([CH3:27])=[CH:10][CH:11]=2)[N:6]=1)=[O:4]参加物
3
実験手順
To a solution of 3.00 g 4-Benzyloxycarbonylmethoxy-7-methyl-quinoline-2-carboxylic acid methyl ester in 50 ml ethanol were added under argon 0.3 g Pd/C (10%) and the suspension was stirred under an atmosphere of hydrogen (3 bar) for 16 h. The suspension was filtered over a plug of Celite® and washed with ethanol. The crude product was obtained after evaporation of the solvent. Yield: 1.90 g.
後処理
- filtrationThe suspension was filtered over a plug of Celite®
- washwashed with ethanol