Hydrochloric Acid → Methyl 4-methylnaphthalene-1-carboxylate

HRID 11857ノート

反応式

HRID 11857 の反応式
[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]([OH:14])=[O:13])=[CH:4][CH:3]=1.Cl.[CH3:16]O>>[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]([O:14][CH3:16])=[O:13])=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 30142854-Methyl-1-naphthalenecarboxylic acid

生成物 1

HCID 21973653Methyl 4-methylnaphthalene-1-carboxylate

実験手順

Commercially available 4-methyl-1-naphthalenecarboxylic acid (250.6 mg) was dissolved in methanol (7.5 ml). Hydrogen chloride gas was blown into the solution for five minutes while cooling with ice. Then, the mixture was stirred for 19 hours at room temperature and the solvent was removed by distillation. The residue was dissolved in chloroform, washed with 1 mol/l aqueous solution of sodium hydroxide, and dried over anhydrous sodium sulfate. The solvent was removed by distillation. The residue was dried under reduced pressure to obtain the target compound (269.9 mg) as colorless oil.

後処理

  1. temperaturewhile cooling with ice
  2. customthe solvent was removed by distillation
  3. dissolutionThe residue was dissolved in chloroform
  4. washwashed with 1 mol/l aqueous solution of sodium hydroxide
  5. dry with materialdried over anhydrous sodium sulfate
  6. customThe solvent was removed by distillation
  7. customThe residue was dried under reduced pressure

出典と根拠

ORDレコード
ord-b8d808e82a4642758ddd699886c22acc
出典データセット
uspto-grants-2006_08
特許番号
US07098215B2

反応ノート

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