2-Bromo-4'-methylacetophenone → 6-(Methoxycarbonyl)-2-(4-methylphenyl)imidazo[1,2-A]pyridine

HRID 1185991ノート

反応式

HRID 1185991 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][CH:6]=1)=O.[NH2:12][C:13]1[CH:18]=[CH:17][C:16]([C:19]([O:21][CH3:22])=[O:20])=[CH:15][N:14]=1>C(O)C>[C:8]1([CH3:11])[CH:9]=[CH:10][C:5]([C:3]2[N:12]=[C:13]3[CH:18]=[CH:17][C:16]([C:19]([O:21][CH3:22])=[O:20])=[CH:15][N:14]3[CH:2]=2)=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 692722-Bromo-4'-methylacetophenoneHCID 737487Methyl 6-aminonicotinate

生成物 1

HCID 160882316-(Methoxycarbonyl)-2-(4-methylphenyl)imidazo[1,2-A]pyridine収率 85.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2-Bromo-4′-methylacetophenone 2 (14.5 g, 65.1 mmol) was added to a hot solution of methyl 2-aminopyridine-5-carboxylate 1 (9.0 g, 61.1 mmol) in ethanol (280 ml). The solution was then heated at reflux for 6 h, cooled to room temperature and the white solid filtered and washed with ethanol to give methyl 2-(4-tolyl)-imidazo[1,2-a]pyridine-6-carboxylate 3 (13.9 g, 80%).

後処理

  1. temperatureThe solution was then heated
  2. temperatureat reflux for 6 h
  3. filtrationthe white solid filtered
  4. washwashed with ethanol

出典と根拠

ORDレコード
ord-07e84fe958d141a1bd7ef71b27958dfa
出典データセット
uspto-grants-2014_03
特許番号
US08673652B2

反応ノート

読み込み中…