(Trifluoromethyl)trimethylsilane → HCID 67401736、化合物

HRID 1186356

反応式

HRID 1186356 の反応式
[N:1]1([C:6]2[N:11]=[CH:10][C:9]([CH:12]=[O:13])=[CH:8][CH:7]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[F:14][C:15]([Si](C)(C)C)([F:17])[F:16].[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[N:1]1([C:6]2[CH:7]=[CH:8][C:9]([CH:12]([OH:13])[C:15]([F:17])([F:16])[F:14])=[CH:10][N:11]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

参加物

5

反応物 3

HCID 552549(Trifluoromethyl)trimethylsilaneHCID 2724141Tetrabutylammonium FluorideHCID 27947756-(Pyrrolidin-1-yl)pyridine-3-carbaldehyde

生成物 1

HCID 67401736HCID 67401736、化合物収率 94%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

According to Reference Example 8-12, by use of 6-(pyrrolidin-1-yl)-3-pyridinecarboxaldehyde (173 mg, 0.982 mmol), (trifluoromethyl)trimethylsilane (174 μL, 1.18 mmol), tetrabutylammonium fluoride (a 1.0 mol/L solution in tetrahydrofuran, 98.0 μL, 0.098 mmol) and tetrahydrofuran (5.0 mL), the mixture was stirred and reacted at room temperature for 30 minutes. Then, slurry purification was performed using hexane, to give 2-(pyrrolidin-1-yl)-5-(2,2,2-trifluoro-1-hydroxyethyl)-pyridine (Compound DH) (227 mg, yield: 94%).

後処理

  1. customreacted at room temperature for 30 minutes
  2. customThen, slurry purification

出典と根拠

ORDレコード
ord-fd9eef4168e448158e86ec565aff527f
出典データセット
uspto-grants-2014_03
特許番号
US08673908B2

関連ノート

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