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Potassium Carbonate → 5-Thiazolemethanol, 2-chloro-alpha-(trifluoromethyl)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | (Trifluoromethyl)trimethylsilane | HCID 552549 | — |
| 反応物 | 2-Chloro-1,3-thiazole-5-carbaldehyde | HCID 1479765 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 5-Thiazolemethanol, 2-chloro-alpha-(trifluoromethyl)- | HCID 67401954 | — |
反応手順
According to Reference Example 8-2, by use of 2-chlorothiazole-5-carbaldehyde (300 mg, 2.03 mmol) dissolved in N,N-dimethylformamide (4 mL), potassium carbonate (56 mg, 0.41 mmol) and (trifluoromethyl)trimethylsilane (0.360 mL, 2.44 mmol), the mixture was stirred and reacted at room temperature for 1.3 hours. Then, purification by preparative thin-layer chromatography (chloroform/methanol=15/1) was performed to give
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08673908B2 |
| 出典データセット | uspto-grants-2014_03 |
| ORD ID | ord-9fb403dcf9c6448d8721f7ff0532fff1 |
| 出典メモ | uspto-grants-2014_03 |