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Potassium Carbonate → 2,2,2-Trifluoro-1-(2-morpholinothiazol-5-yl)ethanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | (Trifluoromethyl)trimethylsilane | HCID 552549 | — |
| 反応物 | 2-(Morpholin-4-yl)-1,3-thiazole-5-carbaldehyde | HCID 1479770 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2,2,2-Trifluoro-1-(2-morpholinothiazol-5-yl)ethanol | HCID 67401740 | 65.1% |
反応手順
According to Reference Example 8-2, by use of 2-morpholinothiazole-5-carbaldehyde (177 mg, 0.893 mmol) dissolved in N,N-dimethylformamide (5.3 mL), potassium carbonate (25 mg, 0.18 mmol) and (trifluoromethyl)trimethylsilane (0.198 mL, 1.34 mmol), the mixture was stirred and reacted at room temperature for 2.3 hours. Then, purification by preparative thin-layer chromatography (chloroform/methanol=15/1) was performed to give 2,2,2-trifluoro-1-(2-morpholinothiazol-5-yl)ethanol (Compound DY) (156 mg, yield: 65%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08673908B2 |
| 出典データセット | uspto-grants-2014_03 |
| ORD ID | ord-c2161b8b710a4619b109609db1ebd983 |
| 出典メモ | uspto-grants-2014_03 |