3-Pyridinepropanol → 3-(Pyridin-3-yl)propanal

HRID 1186391

反応式

HRID 1186391 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH2:9][OH:10])[CH:2]=1.CC(OI1(OC(C)=O)(OC(C)=O)OC(=O)C2C=CC=CC1=2)=O>ClCCl>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][CH2:8][CH:9]=[O:10])[CH:2]=1

参加物

4

反応物 2

HCID 178613-PyridinepropanolHCID 159087Triacetoxyperiodinane

生成物 1

HCID 111054123-(Pyridin-3-yl)propanal収率 61%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3-Pyridinepropanol (300 mg, 2.2 mmol) was dissolved in dichloromethane (5 mL). To this, the Dess-Martin reagent (1.0 g) was added with cooling in an ice bath and the mixture was stirred at the same temperature for 2 hours and successively at room temperature for 3 hours. The solvent in the reaction mixture was evaporated off under reduced pressure, and the residue was purified by silica gel column chromatography (chloroform/methanol=1/0 to 10/1) to give 3-(pyridin-3-yl)propanal (180 mg, yield: 61%).

後処理

  1. temperaturewith cooling in an ice bath
  2. customThe solvent in the reaction mixture was evaporated off under reduced pressure
  3. customthe residue was purified by silica gel column chromatography (chloroform/methanol=1/0 to 10/1)

出典と根拠

ORDレコード
ord-d0c2e372d0714bb590a9d46cd7f14c27
出典データセット
uspto-grants-2014_03
特許番号
US08673908B2

関連ノート

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