Ammonia → 2,4-Dimethylthiazole-5-sulfonamide

HRID 1186437ノート

反応式

HRID 1186437 の反応式
[CH3:1][C:2]1[S:3][C:4]([S:8](Cl)(=[O:10])=[O:9])=[C:5]([CH3:7])[N:6]=1.[NH3:12]>CO>[CH3:1][C:2]1[S:3][C:4]([S:8]([NH2:12])(=[O:10])=[O:9])=[C:5]([CH3:7])[N:6]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 2776248Dimethyl-1,3-thiazole-5-sulfonyl chloride

生成物 1

HCID 128731882,4-Dimethylthiazole-5-sulfonamide収率 34%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

According to Reference Example 9-7, by use of 2,4-dimethylthiazole-5-sulfonyl chloride (250 mg, 1.1 mmol) and a 7 mol/L solution of ammonia in methanol (2 mL), the mixture was stirred and reacted at room temperature for 2 hours. Then, purification by silica gel column chromatography (chloroform/methanol=1/0 to 20/1) was performed to give 2,4-dimethylthiazole-5-sulfonamide (Compound FL) (60 mg, yield: 34%).

後処理

  1. customreacted at room temperature for 2 hours
  2. customThen, purification by silica gel column chromatography (chloroform/methanol=1/0 to 20/1)

出典と根拠

ORDレコード
ord-13b3e91a772c45de955e504fea7db96c
出典データセット
uspto-grants-2014_03
特許番号
US08673908B2

反応ノート

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