Oxalic Acid → 5-Trifluoromethyl-quinazoline-2,4-diamine

HRID 1186457ノート

反応式

HRID 1186457 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([NH2:7])=[C:3]([NH2:8])[CH:2]=1.[C:9](O)(=[O:13])[C:10](O)=[O:11]>Cl>[NH:7]1[C:10](=[O:11])[C:9](=[O:13])[NH:8][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][C:4]1=2

参加物

4

反応物 2

HCID 971Oxalic AcidHCID 59183,4-Diaminopyridine

生成物 1

HCID 107970835-Trifluoromethyl-quinazoline-2,4-diamine収率 107.2%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

反応条件

温度
100 °C

実験手順

Pyridine-3,4-diamine (2.00 g, 18.3 mmol) and oxalic acid (1.96 g, 20.2 mmol) were dissolved in an aqueous hydrochloric acid solution (2.00 M, 20.0 mL) and the mixture was stirred with heat at 100° C. for 24 hours. After the reaction mixture was cooled to room temperature, the precipitate was collected by filtration and dried under reduced pressure. Thus, pyrido[3,4-b]pyrazine-2,3(1H,4H)-dione (3.20 g, 74%) was obtained.

後処理

  1. temperatureAfter the reaction mixture was cooled to room temperature
  2. filtrationthe precipitate was collected by filtration
  3. customdried under reduced pressure

出典と根拠

ORDレコード
ord-ba671b75e81a4b0da17c094fb65b3474
出典データセット
uspto-grants-2014_03
特許番号
US08673908B2

反応ノート

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