4-Aminotetrahydropyran → HCID 66548082、化合物

HRID 1186468

反応式

HRID 1186468 の反応式
C(OC(=O)[N:7]([C:14]1[C:15]2[N:16]([C:20](Br)=[CH:21][N:22]=2)[CH:17]=[CH:18][N:19]=1)[CH2:8][CH2:9][S:10]([CH3:13])(=[O:12])=[O:11])(C)(C)C.CS[C:27]1[N:32]=[C:31]([Sn](CCCC)(CCCC)CCCC)[CH:30]=[CH:29][N:28]=1.[NH2:46][CH:47]1[CH2:52][CH2:51][O:50][CH2:49][CH2:48]1>>[CH3:13][S:10]([CH2:9][CH2:8][NH:7][C:14]1[C:15]2[N:16]([C:20]([C:31]3[CH:30]=[CH:29][N:28]=[C:27]([NH:46][CH:47]4[CH2:52][CH2:51][O:50][CH2:49][CH2:48]4)[N:32]=3)=[CH:21][N:22]=2)[CH:17]=[CH:18][N:19]=1)(=[O:11])=[O:12]

参加物

4

反応物 3

HCID 4192234-AminotetrahydropyranHCID 27632612-(Methylthio)-4-(tributylstannyl)pyrimidineHCID 68226902(3-Bromo-imidazo[1,2-a]pyrazin-8-yl)-(2-methanesulfonyl-ethyl)-carbamic acid tert-butyl ester

生成物 1

HCID 66548082HCID 66548082、化合物

実験手順

(2-Methanesulfonyl-ethyl)-{3-[2-(tetrahydro-pyran-4-ylamino)-pyrimidin-4-yl]-imidazo[1,2-a]pyrazin-8-yl}-amine was prepared by a process analogous to that described in Example 12 starting from (3-bromo-imidazo[1,2-a]pyrazin-8-yl)-(2-methanesulfonyl-ethyl)-carbamic acid tert-butyl ester (from Example 5 supra), 2-methylsulfanyl-4-tributylstannanyl-pyrimidine, and 4-amino-tetrahydropyran. LC-MS: [M+H]+ 418.2.

出典と根拠

ORDレコード
ord-96ff4bb949454c92910817c59c4c7eb1
出典データセット
uspto-grants-2014_03
特許番号
US08673905B2

関連ノート

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