反応式
Br[C:2]1[N:6]2[CH:7]=[CH:8][N:9]=[C:10]([NH:11][CH2:12][CH2:13][OH:14])[C:5]2=[N:4][CH:3]=1.CS[C:17]1[N:22]=[C:21]([Sn](CCCC)(CCCC)CCCC)[CH:20]=[CH:19][N:18]=1.[CH3:36][NH2:37]>>[CH3:36][NH:37][C:17]1[N:22]=[C:21]([C:2]2[N:6]3[CH:7]=[CH:8][N:9]=[C:10]([NH:11][CH2:12][CH2:13][OH:14])[C:5]3=[N:4][CH:3]=2)[CH:20]=[CH:19][N:18]=1参加物
4
実験手順
2-[3-(2-Methylamino-pyrimidin-4-yl)-imidazo[1,2-a]pyrazin-8-ylamino]-ethanol was prepared by a process analogous to that described in Example 12 starting from 2-(3-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-ethanol (from Example 2 supra), 2-methylsulfanyl-4-tributylstannanyl-pyrimidine, and methylamine. LC-MS: [M+H]+ 286.2.
出典と根拠
- ORDレコード
- ord-9a53e6341d92478dbbcb909c61d09903
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08673905B2
関連ノート
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