Hydrochloric Acid → N1-{6-[8-(4-methyl-piperazin-1-yl)-imidazo[1,2-a]pyrazin-3-yl]-pyridin-2-yl}-1-phenyl-ethane-1,2-diamine

HRID 1186509ノート

反応式

HRID 1186509 の反応式
C(OC(=O)[NH:7][CH2:8][CH:9]([NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[C:19]([C:23]2[N:27]3[CH:28]=[CH:29][N:30]=[C:31]([N:32]4[CH2:37][CH2:36][N:35]([CH3:38])[CH2:34][CH2:33]4)[C:26]3=[N:25][CH:24]=2)[N:18]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)(C)(C)C.Cl>C(O)C>[CH3:38][N:35]1[CH2:34][CH2:33][N:32]([C:31]2[C:26]3[N:27]([C:23]([C:19]4[N:18]=[C:17]([NH:16][CH:9]([C:10]5[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=5)[CH2:8][NH2:7])[CH:22]=[CH:21][CH:20]=4)=[CH:24][N:25]=3)[CH:28]=[CH:29][N:30]=2)[CH2:37][CH2:36]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 68226762(2-{6-[8-(4-Methyl-piperazin-1-yl)-imidazo[1,2-a]pyrazin-3-yl]-pyridin-2-ylamino}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

生成物 1

HCID 66548626N1-{6-[8-(4-methyl-piperazin-1-yl)-imidazo[1,2-a]pyrazin-3-yl]-pyridin-2-yl}-1-phenyl-ethane-1,2-diamine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

The mixture of (2-{6-[8-(4-methyl-piperazin-1-yl)-imidazo[1,2-a]pyrazin-3-yl]-pyridin-2-ylamino}-2-phenyl-ethyl)-carbamic acid tert-butyl ester (30 mg, 0.06 mmol) and concentrated HCl (3 mL) in ethanol (3 mL) was stirred at room temperature for 15 hours. The reaction mixture was then concentrated under reduced pressure to give N1-{6-[8-(4-methyl-piperazin-1-yl)-imidazo[1,2-a]pyrazin-3-yl]-pyridin-2-yl}-1-phenyl-ethane-1,2-diamine; hydrochloride. (Yield 40 mg). 1HNMR (300 MHz, CD3OD): δ 8.54 (brs, 1H), 8.13 (s, 1H), 7.64-7.46 (m, 3H), 7.31-7.10 (m, 5H), 6.92 (d, 1H, J=8.1 Hz), 5.44 (brs, 3H), 3.93 (brs, 2H), 3.72-3.69 (m, 2H), 3.52-3.34 (m, 4H), 2.92 (s, 3H). LC-MS: [M+H]+ 429.

後処理

  1. concentrationThe reaction mixture was then concentrated under reduced pressure

出典と根拠

ORDレコード
ord-c8a66478abf643629f4abb3ead173b25
出典データセット
uspto-grants-2014_03
特許番号
US08673905B2

反応ノート

読み込み中…