4-(3-chloro-1,4-dioxo-1,4-dihydro-naphthalen-2-ylamino)-N-(2-methoxy-phenyl)-benzenesulfonamide → N-cyclopropyl-3-(1-oxo-4-(thiophen-2-ylsulfonylimino)-1,4-dihydronaphthalen-2-ylthio)propanamide

HRID 1186667

反応式

HRID 1186667 の反応式
ClC1C(=O)C2C(=CC=CC=2)C(=O)C=1NC1C=CC(S(NC2C=CC=CC=2OC)(=O)=O)=CC=1.Cl[C:34]1[CH:35]=[C:36]([S:40]([N:43]=[C:44]2[C:53]3[C:48](=[CH:49][CH:50]=[CH:51][CH:52]=3)[C:47](=[O:54])[C:46](Cl)=[CH:45]2)(=[O:42])=[O:41])[S:37][C:38]=1Cl.[SH:56][CH2:57][CH2:58][C:59]([NH:61][CH:62]1[CH2:64][CH2:63]1)=[O:60]>>[CH:62]1([NH:61][C:59](=[O:60])[CH2:58][CH2:57][S:56][C:46]2[C:47](=[O:54])[C:48]3[C:53]([C:44](=[N:43][S:40]([C:36]4[S:37][CH:38]=[CH:34][CH:35]=4)(=[O:42])=[O:41])[CH:45]=2)=[CH:52][CH:51]=[CH:50][CH:49]=3)[CH2:64][CH2:63]1

参加物

4

反応物 3

HCID 446086564-(3-chloro-1,4-dioxo-1,4-dihydro-naphthalen-2-ylamino)-N-(2-methoxy-phenyl)-benzenesulfonamideHCID 673306684,5-dichloro-N-(3-chloro-4-oxonaphthalen-1(4H)-ylidene)thiophene-2-sulfonamideHCID 866565673-mercapto-N-cyclopropylpropanamide

生成物 1

HCID 67330263N-cyclopropyl-3-(1-oxo-4-(thiophen-2-ylsulfonylimino)-1,4-dihydronaphthalen-2-ylthio)propanamide

実験手順

5.2.43 N-cyclopropyl-3-(1-oxo-4-(thiophen-2-ylsulfonylimino)-1,4-dihydronaphthalen-2-ylthio)propanamide (13h) was prepared according to the procedure for 13d except using 4,5-dichloro-N-(3-chloro-4-oxonaphthalen-1(4H)-ylidene)thiophenesulfonamide (12c) and 3-mercapto-N-cyclopropylpropanamide which afforded the title compound 20 mg (37%) as a yellow solid, m.p.: ° C.

出典と根拠

ORDレコード
ord-e70cfc4352a9457d937cb9b8a5009772
出典データセット
uspto-grants-2014_03
特許番号
US08673910B2

関連ノート

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