1,4-Dioxane hydrochloride → 1-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine

HRID 1187133ノート

反応式

HRID 1187133 の反応式
CC([CH:5]1[CH2:10][N:9]([CH2:11][CH:12]2[C:21]3[C:16](=[C:17]([Br:22])[CH:18]=[CH:19][CH:20]=3)[CH2:15][CH2:14][O:13]2)[CH2:8][CH2:7][N:6]1C([O-])=O)(C)C.Cl.O1CCOCC1>C(Cl)Cl>[Br:22][C:17]1[CH:18]=[CH:19][CH:20]=[C:21]2[C:16]=1[CH2:15][CH2:14][O:13][CH:12]2[CH2:11][N:9]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:10]1

参加物

4

反応物 2

HCID 204431481,4-Dioxane hydrochlorideHCID 866473201,1-dimethylethyl-4-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine-1-carboxylate

生成物 1

HCID 666439161-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 1,1-dimethylethyl-4-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine-1-carboxylate (480 mg, 1.2 mmol) in 10 mL of DCM was added 10 mL of 4N HCl/dioxane, and then stirred at room temperature for 2 hours. The solvents was removed under vacuum to afford 1-[(5-bromo-3,4-dihydro-1H-isochromen-1-yl)methyl]piperazine.

後処理

  1. customThe solvents was removed under vacuum

出典と根拠

ORDレコード
ord-4941a95b135245828ff81b3dc3310475
出典データセット
uspto-grants-2014_03
特許番号
US08673920B2

反応ノート

読み込み中…