Formamide → 6-Chloroquinazolin-4-amine

HRID 1187255ノート

反応式

HRID 1187255 の反応式
[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[C:4]#[N:5].O.[CH:12]([NH2:14])=O>>[NH2:5][C:4]1[C:3]2[C:2](=[CH:9][CH:8]=[C:7]([Cl:10])[CH:6]=2)[N:1]=[CH:12][N:14]=1

参加物

4

反応物 3

HCID 713FormamideHCID 962WaterHCID 800192-Amino-5-chlorobenzonitrile

生成物 1

HCID 3202476-Chloroquinazolin-4-amine収率 95%

実験手順

A solution of 2-amino-5-chlorobenzonitrile (1.07 g, 7.0 mmol) in formamide (20 ml) was heated at 180° C. for 6 hours. After cooling to room temperature, water (30 ml) was added to the reaction mixture. The precipitate was collected by filtration, washed with water and dried over P2O5, yielding the title compound as a grey solid (1.2 g, yield: 95%) which was characterized by its mass spectrum as follows: MS (m/z): 180 ([M+H]+, 100).

後処理

  1. filtrationThe precipitate was collected by filtration
  2. washwashed with water
  3. dry with materialdried over P2O5

出典と根拠

ORDレコード
ord-adf704e9d21d4fca9b488f33b293ef1e
出典データセット
uspto-grants-2014_03
特許番号
US08673929B2

反応ノート

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