Potassium Carbonate → (S)-4-(2-(4-fluorobenzylamino)-4-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-N-(2-(dimethylamino)ethyl)benzamide

反応式

[F:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][NH:7][C:8]2[N:17]=[C:16]([O:18][C@H:19]3[CH2:23][CH2:22][O:21][CH2:20]3)[C:15]3[C:10](=[CH:11][CH:12]=[C:13](Br)[CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:33][N:34]([CH3:49])[CH2:35][CH2:36][NH:37][C:38]([C:40]1[CH:45]=[CH:44][C:43](B(O)O)=[CH:42][CH:41]=1)=[O:39]>CN(C=O)C.O>[F:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][NH:7][C:8]2[N:17]=[C:16]([O:18][C@H:19]3[CH2:23][CH2:22][O:21][CH2:20]3)[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:43]4[CH:44]=[CH:45][C:40]([C:38]([NH:37][CH2:36][CH2:35][N:34]([CH3:33])[CH3:49])=[O:39])=[CH:41][CH:42]=4)[CH:14]=3)[N:9]=2)=[CH:4][CH:3]=1