Methanol → 4-Methoxy-7h-pyrrolo[2,3-d]pyrimidine
反応式
Cl[C:2]1[C:3]2[CH:10]=[CH:9][NH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[OH-:11].[K+].O.[CH3:14]O>>[CH3:14][O:11][C:2]1[C:3]2[CH:10]=[CH:9][NH:8][C:4]=2[N:5]=[CH:6][N:7]=1参加物
5
反応条件
- 温度
- 60 °C
実験手順
To 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (1, 3.5 g, 23.0 mmol) in 70 mL of methanol, potassium hydroxide (2.3 g, 41.0 mmol) is added and the reaction stirred at 60° C. overnight, then poured into water and extracted with ethyl acetate. The organic layer is separated and dried over sodium sulfate, filtered and the filtrate concentrated under vacuum to provide the desired compound (2, 3.20 g).
後処理
- extractionextracted with ethyl acetate
- customThe organic layer is separated
- dry with materialdried over sodium sulfate
- filtrationfiltered
- concentrationthe filtrate concentrated under vacuum
出典と根拠
- ORDレコード
- ord-8849d3a8935e495e97965baf706eef26
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08673928B2
反応ノート
読み込み中…