Hydrochloric Acid → (R)-ethyl 2-(pyrrolidin-3-yloxy)acetate hydrochloride
反応式
[CH2:1]([O:3][C:4]([CH2:6][O:7][C@@H:8]1[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]1)=[O:5])[CH3:2].[ClH:20]>O1CCOCC1>[ClH:20].[NH:10]1[CH2:11][CH2:12][C@@H:8]([O:7][CH2:6][C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:9]1参加物
4
実験手順
tert-Butyl (3R)-3-(ethoxycarbonylmethoxy)pyrrolidine-1-carboxylate (4.0 g, 15.42 mmol) was dissolved in 4N HCl in 1,4-dioxane (50 mL), stirred at ambient temperature for 3 hrs, evaporated, co-evaporated with 1,4-dioxane (3×50 mL) and dried under high vacuum to give (R)-ethyl 2-(pyrrolidin-3-yloxy)acetate hydrochloride as an orange oil that solidified on standing.
後処理
- customevaporated
- customdried under high vacuum
出典と根拠
- ORDレコード
- ord-9a58429ed3de4843a7f64ffefc319259
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08673938B2
反応ノート
読み込み中…