Benzylamine → HCID 59408775、化合物

HRID 1188105ノート

反応式

HRID 1188105 の反応式
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[C:10]1[S:11][C:12]([C:15]([NH:17][C:18]2[S:19][C:20]([C:23]3[CH:28]=[CH:27][C:26]([CH3:29])=[CH:25][CH:24]=3)=[CH:21][N:22]=2)=[O:16])=[CH:13][N:14]=1>CN(C=O)C.CCOC(C)=O>[CH2:1]([NH:8][C:10]1[S:11][C:12]([C:15]([NH:17][C:18]2[S:19][C:20]([C:23]3[CH:28]=[CH:27][C:26]([CH3:29])=[CH:25][CH:24]=3)=[CH:21][N:22]=2)=[O:16])=[CH:13][N:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 7504BenzylamineHCID 59408735HCID 59408735、化合物

生成物 1

HCID 59408775HCID 59408775、化合物収率 71%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

Benzylamine (0.143 mL, 1.32 mmol) was added to a solution of 2-bromo-N-(5-p-tolylthiazol-2-yl)thiazole-5-carboxamide (250 mg, 0.66 mmol) in DMF (4 mL). The reaction mixture was stirred at reflux for 2 hrs. Then it was diluted with AcOEt and washed with water, dried with Na2SO4 and concentrated. The crude product was purified by precipitation (AcOEt/PE), yielding 2-(benzylamino)-N-(5-p-tolylthiazol-2-yl)thiazole-5-carboxamide (190 mg, 71%) as a solid.

後処理

  1. temperatureat reflux for 2 hrs
  2. washwashed with water
  3. dry with materialdried with Na2SO4
  4. concentrationconcentrated
  5. customThe crude product was purified by precipitation (AcOEt/PE)

出典と根拠

ORDレコード
ord-b1cfb7b10940468c87902e904d28d3c9
出典データセット
uspto-grants-2014_03
特許番号
US08673940B2

反応ノート

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