Chloroform ethylacetate → HCID 86674621、化合物

HRID 1188107ノート

反応式

HRID 1188107 の反応式
[CH2:1]([NH:8][C:9]1[S:10][C:11]([CH2:14][NH:15][C:16]2[S:17][C:18]([C:21]3[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][CH:22]=3)=[CH:19][N:20]=2)=[CH:12][N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(Cl)(Cl)[Cl:29].CCOC(C)=O>Cl>[ClH:29].[ClH:29].[CH2:1]([NH:8][C:9]1[S:10][C:11]([CH2:14][NH:15][C:16]2[S:17][C:18]([C:21]3[CH:22]=[CH:23][C:24]([CH3:27])=[CH:25][CH:26]=3)=[CH:19][N:20]=2)=[CH:12][N:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 21584013Chloroform ethylacetateHCID 25000776HCID 25000776、化合物

生成物 1

HCID 86674621HCID 86674621、化合物収率 10%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

N-Benzyl-5-((5-p-tolylthiazol-2-ylamino)methyl)thiazol-2-amine (20 mg, 0.05 mmol) was dissolved in methanolic HCl (3 N, 1 mL) and CHCl3/AcOEt was added. The precipitated solid was filtered by decantation and dried in vacuo, yielding N-benzyl-5-((5-p-tolylthiazol-2-ylamino)methyl)thiazol-2-amine dihydrochloride as a white solid (11 mg, 10%). Mp. 105-106° C.

後処理

  1. filtrationThe precipitated solid was filtered by decantation
  2. customdried in vacuo

出典と根拠

ORDレコード
ord-be9ec0f6f5d14e3e9b3d9ecb3e02da21
出典データセット
uspto-grants-2014_03
特許番号
US08673940B2

反応ノート

読み込み中…