2-(Chloromethyl)-5-cyclopropyl-1,3,4-thiadiazole → 4-Chloro-1-[(5-cyclopropyl-1,3,4-thiadiazol-2-yl)methyl]-2-(difluoromethyl)-1H-indole-5-carbonitrile

HRID 1188349ノート

反応式

HRID 1188349 の反応式
[Cl:1][C:2]1[C:10]([C:11]#[N:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH:13]([F:15])[F:14])[NH:6]2.Cl[CH2:17][C:18]1[S:19][C:20]([CH:23]2[CH2:25][CH2:24]2)=[N:21][N:22]=1>>[Cl:1][C:2]1[C:10]([C:11]#[N:12])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4]=[C:5]([CH:13]([F:14])[F:15])[N:6]2[CH2:17][C:18]1[S:19][C:20]([CH:23]2[CH2:25][CH2:24]2)=[N:21][N:22]=1

参加物

3

反応物 2

HCID 27576792-(Chloromethyl)-5-cyclopropyl-1,3,4-thiadiazoleHCID 249856324-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile

生成物 1

HCID 249859714-Chloro-1-[(5-cyclopropyl-1,3,4-thiadiazol-2-yl)methyl]-2-(difluoromethyl)-1H-indole-5-carbonitrile

実験手順

Synthesized as described in Example 39 from 4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile and 2-(chloromethyl)-5-cyclopropyl-1,3,4-thiadiazole: MS (ESI) m/z 365 (M+1).

後処理

  1. customSynthesized

出典と根拠

ORDレコード
ord-0699d054fa6a457495c3c0a91af51aa2
出典データセット
uspto-grants-2014_03
特許番号
US08673948B2

反応ノート

読み込み中…