3-Chloro-4-(trifluoromethoxy)benzoic acid → 1-[(5-{3-Chloro-4-[(trifluoromethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)methyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrile

HRID 1188558ノート

反応式

HRID 1188558 の反応式
[C:1]([C:3]1[C:4]([C:17]([F:20])([F:19])[F:18])=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:12][C:13](=[NH:16])[NH:14][OH:15])[CH:7]=[CH:6]2)#[N:2].[Cl:21][C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][C:30]=1[O:31][C:32]([F:35])([F:34])[F:33])[C:25](O)=O>>[Cl:21][C:22]1[CH:23]=[C:24]([C:25]2[O:15][N:14]=[C:13]([CH2:12][N:8]3[C:9]4[C:5](=[C:4]([C:17]([F:19])([F:20])[F:18])[C:3]([C:1]#[N:2])=[CH:11][CH:10]=4)[CH:6]=[CH:7]3)[N:16]=2)[CH:28]=[CH:29][C:30]=1[O:31][C:32]([F:33])([F:34])[F:35]

参加物

3

反応物 2

HCID 27738453-Chloro-4-(trifluoromethoxy)benzoic acidHCID 178509476HCID 178509476、化合物

生成物 1

HCID 578003531-[(5-{3-Chloro-4-[(trifluoromethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)methyl]-4-(trifluoromethyl)-1H-indole-5-carbonitrile

実験手順

Synthesized as described in Example 241 from 2-[5-cyano-4-(trifluoromethyl)-1H-indol-1-yl]-N-hydroxyethanimidamide and 3-chloro-4-[(trifluoromethyl)oxy]benzoic acid: MS (APCI) m/z 488 (M+1).

後処理

  1. customSynthesized

出典と根拠

ORDレコード
ord-81ab646a974e40b49814e88325aa609d
出典データセット
uspto-grants-2014_03
特許番号
US08673948B2

反応ノート

読み込み中…