3-Bromobenzyl bromide → 1-[(3-Bromophenyl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

HRID 1188636ノート

反応式

HRID 1188636 の反応式
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[C:8]([C:11]([F:14])([F:13])[F:12])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=2.[Br:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([CH2:24]Br)[CH:19]=1>>[Br:17][C:18]1[CH:19]=[C:20]([CH2:24][N:3]2[C:4]3[C:9](=[C:8]([C:11]([F:12])([F:14])[F:13])[C:7]([C:15]#[N:16])=[CH:6][CH:5]=3)[CH:10]=[C:2]2[CH3:1])[CH:21]=[CH:22][CH:23]=1

参加物

3

反応物 2

HCID 699793-Bromobenzyl bromideHCID 533093462-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

生成物 1

HCID 674050351-[(3-Bromophenyl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

実験手順

Synthesized as described in Example 4 using 2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 120) and 1-bromo-3-(bromomethyl)benzene: MS (ES) m/z 393 (M+1) and 395 (M+1, isotope).

後処理

  1. customSynthesized

出典と根拠

ORDレコード
ord-2e3fd3a8449d4d36a2fdde35827749b0
出典データセット
uspto-grants-2014_03
特許番号
US08673948B2

反応ノート

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