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HRID 1188652作成日：2026年10月26日

3-(Trifluoromethyl)phenylboronic acid → 2-Methyl-4-(trifluoromethyl)-1-({5-[3-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-3-yl}methyl)-1H-indole-5-carbonitrile

https://huagongshe.com/reaction/1188652

反応式

関与物質

役割名称HCID仕込み量
反応物3-(Trifluoromethyl)phenylboronic acidHCID 2734388—
反応物1-[(5-Chloro-1,2,4-thiadiazol-3-yl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrileHCID 67405013—
生成物2-Methyl-4-(trifluoromethyl)-1-({5-[3-(trifluoromethyl)phenyl]-1,2,4-thiadiazol-3-yl}methyl)-1H-indole-5-carbonitrileHCID 86620710—

反応手順

Synthesized as described in Example 327 using 1-[(5-chloro-1,2,4-thiadiazol-3-yl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 326) and [3-(trifluoromethyl)phenyl]boronic acid: MS (ES) m/z 467 (M+1).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08673948B2
出典データセットuspto-grants-2014_03
ORD IDord-8d03d3be2ec84014818766c65b64ecee
出典メモuspto-grants-2014_03