2,4-Dichloropyrimidine → 2-Chloro-4-(4-phenylbut-1-ynyl)pyrimidine

反応式

[Cl:1][C:2]1[N:7]=[C:6](Cl)[CH:5]=[CH:4][N:3]=1.[CH2:9]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH2:10][C:11]#[CH:12]>>[Cl:1][C:2]1[N:7]=[C:6]([C:12]#[C:11][CH2:10][CH2:9][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:5]=[CH:4][N:3]=1

参加物

反応物 2

HCID 775312,4-Dichloropyrimidine

HCID 1233604-Phenyl-1-butyne

生成物 1

HCID 117014952-Chloro-4-(4-phenylbut-1-ynyl)pyrimidine収率 69%

実験手順

The title compound was prepared in accordance with the general method of Example 1, from 2,4-dichloropyrimidine (250 mg, 1.68 mmol) and 1-(but-3-ynyl)benzene (218 mg, 1.68 mmol). The crude residue was purified by flash chromatography (cyclohexane/AcOEt 9:1) to yield 280 mg (1.15 mmol, 69%) of 2-chloro-4-(4-phenylbut-1-ynyl)pyrimidine as a brown oil.

後処理

customThe crude residue was purified by flash chromatography (cyclohexane/AcOEt 9:1)

出典と根拠

ORDレコード: ord-34c29c83f350429dbf092033011124ff
出典データセット: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08674106B2

反応ノート

読み込み中…

参加物