2-Bromo-5-fluoropyridine → 2-(4-(5-Fluoropyridin-2-yl)but-3-ynyl)benzo[d]thiazole
反応式
Br[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][N:3]=1.[CH2:9]([C:13]1[S:14][C:15]2[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=2[N:17]=1)[CH2:10][C:11]#[CH:12]>>[F:8][C:5]1[CH:6]=[CH:7][C:2]([C:12]#[C:11][CH2:10][CH2:9][C:13]2[S:14][C:15]3[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=3[N:17]=2)=[N:3][CH:4]=1参加物
3
実験手順
The title compound was prepared in accordance with the general method of Example 1, from 2-bromo-5-fluoro-pyridine (103 mg, 0.59 mmol) and 2-but-3-ynyl-benzo[d]thiazole (110 mg, 0.59 mmol, Example 35(A)). The crude residue was purified by flash chromatography (cyclohexane/AcOEt 4:1) to yield 78 mg (0.28 mmol, 47%) of 2-(4-(5-fluoropyridin-2-yl)but-3-ynyl)benzo[d]thiazole as a white solid.
後処理
- customThe crude residue was purified by flash chromatography (cyclohexane/AcOEt 4:1)
出典と根拠
- ORDレコード
- ord-ff95afbeef01436d9560a7d9621d80a7
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08674106B2
反応ノート
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