1-(Trimethylsilyl)prop-1-yne → 1-isopropyl-2-(4-(trimethylsilyl)but-3-ynyl)-1H-benzo[d]imidazole
反応式
Cl[CH2:2][C:3]1[N:7]([CH:8]([CH3:10])[CH3:9])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[N:4]=1.[CH3:15][Si:16]([CH3:21])([CH3:20])[C:17]#[C:18][CH3:19]>>[CH:8]([N:7]1[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[N:4]=[C:3]1[CH2:2][CH2:19][C:18]#[C:17][Si:16]([CH3:21])([CH3:20])[CH3:15])([CH3:10])[CH3:9]参加物
3
実験手順
The title compound was prepared in accordance with the general method of Example 191(D), from of 2-(chloromethyl)-1-isopropyl-1H-benzo[d]imidazole (500 mg, 2.4 mmol) and trimethyl(prop-1-ynyl)silane (323 mg, 2.88 mmol). 1-isopropyl-2-(4-(trimethylsilyl)but-3-ynyl)-1H-benzo[d]imidazole (680 mg, Yield: 100%) was obtained as a brown oil which was used in the next step without any purification.
出典と根拠
- ORDレコード
- ord-15c447aef0ea46d985bf6b92af36ce74
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08674106B2
反応ノート
読み込み中…