Sulfuric Acid → Methyl 8-bromo-4,5-dihydro-4-oxo-1-(tetrahydro-2H-pyran-4-yl)[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylate

HRID 1189478ノート

反応式

HRID 1189478 の反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([NH:6][C:7](=[O:21])[C:8]3[N:9]2[C:12]([CH:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[N:13][N:14]=3)=[CH:4][C:3]=1[C:22]([OH:24])=[O:23].S(=O)(=O)(O)O.[C:30](=O)([O-])O.[Na+]>CO>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([NH:6][C:7](=[O:21])[C:8]3[N:9]2[C:12]([CH:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[N:13][N:14]=3)=[CH:4][C:3]=1[C:22]([O:24][CH3:30])=[O:23]

参加物

5

反応物 3

HCID 1118Sulfuric AcidHCID 516892Sodium BicarbonateHCID 58575207HCID 58575207、化合物

生成物 1

HCID 58575443Methyl 8-bromo-4,5-dihydro-4-oxo-1-(tetrahydro-2H-pyran-4-yl)[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a mixed liquid of 360 mg of 8-bromo-4-oxo-1-(tetrahydro-2H-pyran-4-yl)-4,5-dihydro[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylic acid and 10 mL of methanol was added 2 mL of concentrated sulfuric acid, followed by stirring overnight under a refluxing condition. After cooling to room temperature, the pH was adjusted to about 8 by the addition of a saturated aqueous sodium hydrogen carbonate solution, followed by extraction with a mixed liquid of chloroform and isopropanol. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to obtain 320 mg of methyl 8-bromo-4-oxo-1-(tetrahydro-2H-pyran-4-yl)-4,5-dihydro[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylate as an orange solid.

後処理

  1. extractionfollowed by extraction with a mixed liquid of chloroform and isopropanol
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-ce1f208a5dd6432eb30e3edaeb4a798b
出典データセット
uspto-grants-2014_03
特許番号
US08674096B2

反応ノート

読み込み中…