Hydrochloric Acid → 2-(4-Fluoro-piperidinyl)-4-amino-5-nitro-benzoic acid

HRID 1189637ノート

反応式

HRID 1189637 の反応式
[F:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Cl.F[C:10]1[CH:18]=[C:17]([NH2:19])[C:16]([N+:20]([O-:22])=[O:21])=[CH:15][C:11]=1[C:12]([OH:14])=[O:13]>CN(C=O)C>[F:1][CH:2]1[CH2:7][CH2:6][N:5]([C:10]2[CH:18]=[C:17]([NH2:19])[C:16]([N+:20]([O-:22])=[O:21])=[CH:15][C:11]=2[C:12]([OH:14])=[O:13])[CH2:4][CH2:3]1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 27591594-FluoropiperidineHCID 597853374-Amino-2-fluoro-5-nitrobenzoic acid

生成物 1

HCID 679575752-(4-Fluoro-piperidinyl)-4-amino-5-nitro-benzoic acid

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
50 °C

実験手順

A mixture of 4-fluoropiperidine×HCl (691 mg, 4.9 mmol), TEA (2.2 ml, 16 mmol), 2-fluoro-4-amino-5-nitro-benzoic acid (900 mg, 4.5 mmol) and DMF (15 mL) is stirred for 4.5 h at 50° C. Then the mixture is concentrated, diluted with water and the precipitate is filtered and dried.

後処理

  1. concentrationThen the mixture is concentrated
  2. additiondiluted with water
  3. filtrationthe precipitate is filtered
  4. customdried

出典と根拠

ORDレコード
ord-35ee84f79cc6462dbbf0a5b683efb792
出典データセット
uspto-grants-2014_03
特許番号
US08674113B2

反応ノート

読み込み中…