Hydrochloric Acid → 2-Chloro-4-(methylamino)-5-nitrobenzoic acid

HRID 1189642ノート

反応式

HRID 1189642 の反応式
[CH3:1][NH2:2].[Cl:3][C:4]1[CH:12]=[C:11](F)[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7].Cl>O>[Cl:3][C:4]1[CH:12]=[C:11]([NH:2][CH3:1])[C:10]([N+:14]([O-:16])=[O:15])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 6329Methylamine2 回HCID 72108282-Chloro-4-fluoro-5-nitrobenzoic Acid

生成物 1

HCID 679575072-Chloro-4-(methylamino)-5-nitrobenzoic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

Methylamine (40% aq solution, 8.25 mL) is added to an ice-cooled mixture of 2-chloro-4-fluoro-5-nitro-benzoic acid (7.00 g, 31 mmol) and 70 mL water. After 2 h additional 0.5 mL methylamine solution is added and it is stirred for additional 3 h. Then 200 mL of water and 47 mL 1N aq HCl are added and the resulting precipitate is filtered off, washed with water and dried.

後処理

  1. temperaturecooled
  2. filtrationthe resulting precipitate is filtered off
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-8d60785c8f6441819d6d5a234b3e4897
出典データセット
uspto-grants-2014_03
特許番号
US08674113B2

反応ノート

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