Diisopropylcarbodiimide → HCID 178457019、化合物
反応式
[F:1][C:2]([F:27])([F:26])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:25])[C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH:18][CH3:19])=[CH:13][C:12]=2[N:20]([CH3:24])[CH2:21][C:22]#[CH:23])[CH2:5][CH2:4]1.[Cl:28][C:29]1[C:42]([N:43]=[C:44]=S)=[C:41]([Cl:46])[CH:40]=[CH:39][C:30]=1[CH2:31][NH:32][C:33](=[O:38])[C:34]([CH3:37])([CH3:36])[CH3:35].CC(C)N=C=NC(C)C>CN(C=O)C>[F:1][C:2]([F:26])([F:27])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10]([C:11]2[C:12]([N:20]([CH3:24])[CH2:21][C:22]#[CH:23])=[CH:13][C:14]3[N:18]([CH3:19])[C:44]([NH:43][C:42]4[C:41]([Cl:46])=[CH:40][CH:39]=[C:30]([CH2:31][NH:32][C:33](=[O:38])[C:34]([CH3:37])([CH3:36])[CH3:35])[C:29]=4[Cl:28])=[N:17][C:15]=3[CH:16]=2)=[O:25])[CH2:5][CH2:4]1参加物
5
実験手順
The title compound is prepared in analogy to 6c from N-(trans-4-trifluoromethyl-cyclohexyl)-2-[N-methyl-N-propargylamino]-4-methylamino-5-amino-benzoic acid amide (50 mg, 0.13 mmol), and N-(2,4-dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide (41 mg, 0.13 mmol), DIC (20 μL) and DMF (2.0 mL).