6-(4-Methylpiperazin-1-yl)pyridin-3-amine → 8-Benzo[b]thiophen-3-yl-quinoxaline-5-carboxylic acid [6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-amide

HRID 1189775ノート

反応式

HRID 1189775 の反応式
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[N:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[S:15]1[CH:19]=[C:18]([C:20]2[C:29]3[N:28]=[CH:27][CH:26]=[N:25][C:24]=3[C:23]([C:30](O)=[O:31])=[CH:22][CH:21]=2)[C:17]2[CH:33]=[CH:34][CH:35]=[CH:36][C:16]1=2>C(Cl)Cl.CO>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[N:13]=[CH:12][C:11]([NH:14][C:30]([C:23]3[C:24]4[N:25]=[CH:26][CH:27]=[N:28][C:29]=4[C:20]([C:18]4[C:17]5[CH:33]=[CH:34][CH:35]=[CH:36][C:16]=5[S:15][CH:19]=4)=[CH:21][CH:22]=3)=[O:31])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1

参加物

4

反応物 2

HCID 27633906-(4-Methylpiperazin-1-yl)pyridin-3-amineHCID 669146368-Benzo[b]thiophen-3-yl-quinoxaline-5-carboxylic acid

生成物 1

HCID 445159788-Benzo[b]thiophen-3-yl-quinoxaline-5-carboxylic acid [6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-amide

試薬・触媒・溶媒 1

HCID 21226129Dichloromethane methanol溶媒

実験手順

The title compound was prepared in analogy to the procedure described in Step 14.1 but stirring the reaction mixture for 20 h at rt, using 6-(4-methylpiperazin-1-yl)-pyridin-3-ylamine (prepared as described in Example 33 but using N-methyl-piperazine in Step 33.2) and 8-benzo[b]thiophen-3-yl-quinoxaline-5-carboxylic acid (Example 59). Title compound: ESI-MS: 481.0 [M+H]+; tR=3.81 min (System 1); TLC: Rf=0.40 (DCM/MeOH, 9:1).

後処理

  1. customThe title compound was prepared in analogy to the procedure

出典と根拠

ORDレコード
ord-5f384e5eb4e64537bed328c7dfad81e3
出典データセット
uspto-grants-2014_03
特許番号
US08674099B2

反応ノート

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