2-Chloro-4-methoxybenzeneboronic acid → 8-(2-Chloro-5-methoxy-phenyl)-quinoxaline-5-carboxylic acid [3-(4-ethyl-piperazin-1-yl)-phenyl]-amide

HRID 1189777

反応式

HRID 1189777 の反応式
[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]2[CH:10]=[C:11]([CH:13]=[CH:14][CH:15]=2)[NH2:12])[CH2:5][CH2:4]1)[CH3:2].[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][C:18]=1[C:25]1[C:34]2[N:33]=[CH:32][CH:31]=[N:30][C:29]=2[C:28]([C:35](O)=[O:36])=[CH:27][CH:26]=1.ClC1C=C(OC)C=CC=1B(O)O>>[CH2:1]([N:3]1[CH2:4][CH2:5][N:6]([C:9]2[CH:10]=[C:11]([NH:12][C:35]([C:28]3[C:29]4[N:30]=[CH:31][CH:32]=[N:33][C:34]=4[C:25]([C:18]4[CH:19]=[C:20]([O:23][CH3:24])[CH:21]=[CH:22][C:17]=4[Cl:16])=[CH:26][CH:27]=3)=[O:36])[CH:13]=[CH:14][CH:15]=2)[CH2:7][CH2:8]1)[CH3:2]

参加物

4

反応物 3

HCID 27733302-Chloro-4-methoxybenzeneboronic acidHCID 223301053-(4-Ethylpiperazin-1-yl)anilineHCID 669146088-(2-Chloro-5-methoxy-phenyl)quinoxaline-5-carboxylic acid

生成物 1

HCID 445159808-(2-Chloro-5-methoxy-phenyl)-quinoxaline-5-carboxylic acid [3-(4-ethyl-piperazin-1-yl)-phenyl]-amide

実験手順

The title compound was prepared in analogy to the procedure described in Step 14.1 but using 3-(4-ethylpiperazin-1-yl)-aniline (Step 2.1) and 8-(2-chloro-5-methoxy-phenyl)-quinoxaline-5-carboxylic acid. The latter compound was synthesized as described in Steps 1.2-1.7 but using 2-chloro-4-methoxyphenylboronic acid in Step 1.4. Title compound: ESI-MS: 502.1 [M]+; tR=3.57 min (System 3).

後処理

  1. customThe title compound was prepared in analogy to the procedure
  2. customThe latter compound was synthesized

出典と根拠

ORDレコード
ord-f7c4f7266cab4b28a0104360d0ab2d1b
出典データセット
uspto-grants-2014_03
特許番号
US08674099B2

関連ノート

読み込み中…