6-(4-Methylpiperazin-1-yl)pyridin-3-amine → 8-(4-Methyl-thiophen-3-yl)-quinoxaline-5-carboxylic acid [6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-amide

HRID 1189782

反応式

HRID 1189782 の反応式
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[N:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[CH3:15][C:16]1[C:17]([C:21]2[C:30]3[N:29]=[CH:28][CH:27]=[N:26][C:25]=3[C:24]([C:31](O)=[O:32])=[CH:23][CH:22]=2)=[CH:18][S:19][CH:20]=1>>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[N:13]=[CH:12][C:11]([NH:14][C:31]([C:24]3[C:25]4[N:26]=[CH:27][CH:28]=[N:29][C:30]=4[C:21]([C:17]4[C:16]([CH3:15])=[CH:20][S:19][CH:18]=4)=[CH:22][CH:23]=3)=[O:32])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1

参加物

3

反応物 2

HCID 27633906-(4-Methylpiperazin-1-yl)pyridin-3-amineHCID 669145508-(4-Methylthiophen-3-yl)-quinoxaline-5-carboxylic acid

生成物 1

HCID 445162838-(4-Methyl-thiophen-3-yl)-quinoxaline-5-carboxylic acid [6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-amide

実験手順

The title compound was prepared in analogy to the procedure described in Step 14.1 but stirring the reaction mixture for 20 h at rt, using 6-(4-methylpiperazin-1-yl)-pyridin-3-ylamine (prepared as described in Example 33 but using N-methyl-piperazine in Step 33.2) and 8-(4-methyl-thiophen-3-yl)-quinoxaline-5-carboxylic acid (Example 67). Title compound: ESI-MS: 445.0 [M+H]+; tR=3.42 min (System 1).

後処理

  1. customThe title compound was prepared in analogy to the procedure

出典と根拠

ORDレコード
ord-fc239fd019ff4436b24caff88aa2a0ec
出典データセット
uspto-grants-2014_03
特許番号
US08674099B2

関連ノート

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