化工社化工社 化学情報印刷レポート · 研究参考用
Dibutyltin dichloride → HCID 178499286、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dibutyltin dichloride | HCID 12688 | — |
| 反応物 | Phenylsilane | HCID 12752 | — |
| 反応物 | 3-Amino-5-(4,4-dimethyl-cyclohex-1-enyl)-thiophene-2-carboxylic acid methyl ester | HCID 57795435 | — |
| 反応物 | 5-[1,2,4]Triazol-1-yl-heptan-2-one | HCID 67278637 | — |
| 生成物 | HCID 178499286 | HCID 178499286 | 81.4% |
反応手順
Reductive amination of 3-amino-5-(4,4-dimethyl-cyclohex-1-enyl)-thiophene-2-carboxylic acid methyl ester (0.630 g, 2.37 mmol) and 5-[1,2,4]triazol-1-yl-heptan-2-one (0.560 g, 3.39 mmol) was performed under the same conditions previously described (example 3, step I) using dibutyltin dichloride and phenylsilane to give 5-(4,4-Dimethyl-cyclohex-1-enyl)-3-(trans-4-[1,2,4]triazol-1-yl-cyclohexylamino)-thiophene-2-carboxylic acid methyl ester (0.800 g, 64%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08674118B2 |
| 出典データセット | uspto-grants-2014_03 |
| ORD ID | ord-c444bfebbc244ad4bba75e8805664cb2 |
| 出典メモ | uspto-grants-2014_03 |