[5-Amino-6-(4,4-dimethyl-cyclohex-1-enyl)-pyridin-2-yl]-acetic acid ethyl ester → [5-[(5-Cyano-1H-imidazole-2-carbonyl)-amino]-6-(4,4-dimethyl-cyclohex-1-enyl)-pyridin-2-yl]-acetic acid ethyl ester
反応式
[K+].[C:2]([C:4]1[N:5]=[C:6]([C:17]([O-:19])=O)[N:7](COCC[Si](C)(C)C)[CH:8]=1)#[N:3].[CH2:20]([O:22][C:23](=[O:40])[CH2:24][C:25]1[CH:30]=[CH:29][C:28]([NH2:31])=[C:27]([C:32]2[CH2:37][CH2:36][C:35]([CH3:39])([CH3:38])[CH2:34][CH:33]=2)[N:26]=1)[CH3:21]>>[CH2:20]([O:22][C:23](=[O:40])[CH2:24][C:25]1[CH:30]=[CH:29][C:28]([NH:31][C:17]([C:6]2[NH:5][C:4]([C:2]#[N:3])=[CH:8][N:7]=2)=[O:19])=[C:27]([C:32]2[CH2:37][CH2:36][C:35]([CH3:39])([CH3:38])[CH2:34][CH:33]=2)[N:26]=1)[CH3:21]参加物
3
反応物 2
生成物 1
実験手順
The title compound was prepared by coupling 4-cyano-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole-2-carboxylate potassium salt (as prepared in Example 1, step (d)) and [5-amino-6-(4,4-dimethyl-cyclohex-1-enyl)-pyridin-2-yl]-acetic acid ethyl ester (as prepared in the previous step) according to the procedure in Example 34, step (c), followed by SEM deprotection according to the procedure in Example 34, step (d). Mass spectrum (ESI, m/z): Calcd. for C22H25ClN5O3, 408.2 (M+H). found 408.2.