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Ethanolamine → 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-N-(2-hydroxyethyl)-4-nitro-thiophene-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanolamine | HCID 700 | — |
| 反応物 | 5-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid | HCID 60207317 | — |
| 生成物 | 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-N-(2-hydroxyethyl)-4-nitro-thiophene-2-carboxamide | HCID 46932425 | — |
反応手順
Prepared according to the procedure described for example 44 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (35 mg, 0.1 mmol) and 2-hydroxylethylamine (17.6 mg, 0.12 mmol). The title compound was obtained as a solid (7.8 mg, 17.0% yield). MS m/z: 347.80, 349.80 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08680139B2 |
| 出典データセット | uspto-grants-2014_03 |
| ORD ID | ord-04e64880a1fb465aa29df28e1f5fbbb7 |
| 出典メモ | uspto-grants-2014_03 |