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N,N-Dimethylethylenediamine → 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-N-(2-dimethylaminoethyl)-4-nitro-thiophene-2-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,N-Dimethylethylenediamine | HCID 66053 | — |
| 反応物 | 5-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid | HCID 60207317 | — |
| 生成物 | 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-N-(2-dimethylaminoethyl)-4-nitro-thiophene-2-carboxamide | HCID 46932426 | — |
反応手順
Prepared according to the procedure described for example 44 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (35 mg, 0.1 mmol) and N′,N′-dimethylethane-1,2-diamine (7.3 mg, 0.12 mmol). The title compound was obtained as a solid (5.8 mg, 14.8% yield). MS m/z: 421.90, 423.90 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08680139B2 |
| 出典データセット | uspto-grants-2014_03 |
| ORD ID | ord-4c0fa69905dc4b519e28515ba4e131af |
| 出典メモ | uspto-grants-2014_03 |