1-Methylpyrrolidin-3-amine → 5-((3,5-dichloropyridin-4-yl)thio)-N-(1-methylpyrrolidin-3-yl)-4-nitrothiophene-2-carboxamide

HRID 1192115ノート

反応式

HRID 1192115 の反応式
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[CH3:21][N:22]1[CH2:26][CH2:25][CH:24]([NH2:27])[CH2:23]1>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:27][CH:24]2[CH2:25][CH2:26][N:22]([CH3:21])[CH2:23]2)=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

参加物

3

反応物 2

HCID 189403961-Methylpyrrolidin-3-amineHCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid

生成物 1

HCID 602073335-((3,5-dichloropyridin-4-yl)thio)-N-(1-methylpyrrolidin-3-yl)-4-nitrothiophene-2-carboxamide

実験手順

Prepared according to the procedure described for example 44 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (35 mg, 0.1 mmol) and 1-methylpyrrolidin-3-amine (10.0 mg, 0.1 mmol). The title compound was obtained as a solid (4.3 mg, 10% yield). MS m/z: 432.84, 434.84 [M+H]+.

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-34737d161cd3420996f0d730db9c863a
出典データセット
uspto-grants-2014_03
特許番号
US08680139B2

反応ノート

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