Ethyl 4-cyano-5-(methylsulfonyl)-3-phenylthiophene-2-carboxylate → Ethyl 4-cyano-5-((3,5-dichloropyridin-4-yl)thio)-3-phenylthiophene-2-carboxylate
反応式
[C:1]([C:3]1[C:4]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:5]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[S:6][C:7]=1[S:8]([CH3:11])(=O)=O)#[N:2].[Na].[Cl:24][C:25]1[CH:26]=[N:27][CH:28]=[C:29]([Cl:32])C=1S>>[C:1]([C:3]1[C:4]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:5]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[S:6][C:7]=1[S:8][C:11]1[C:25]([Cl:24])=[CH:26][N:27]=[CH:28][C:29]=1[Cl:32])#[N:2]参加物
3
実験手順
Prepared according to the procedure described for step C of example 18 from Ethyl 4-cyano-5-(methylsulfonyl)-3-phenylthiophene-2-carboxylate (0.3 g, 0.89 mmol) from above and 3,5-dichloropyridine-4-thiol sodium salt (0.18 g, 1.0 mmol) at 90° C. for over night. The title product was obtained as a white solid. The crude product was used as such for the next step transformation. MS m/z: 434.98, 436.98 [M+H]+.
後処理
- customPrepared
- customat 90° C.