(R)-1-(2-tert-Butoxycarbonylamino-1-methyl-ethyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl ester → (R)-4-Methyl-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one

HRID 11928

反応式

HRID 11928 の反応式
C(OC(N1C[C@@H](C)N2[C@H](CC3C2=NC(Br)=CC=3)C1)=O)(C)(C)C.C(OC([C:28]1[N:36]([C@H:37]([CH3:47])[CH2:38][NH:39][C:40](OC(C)(C)C)=[O:41])[C:31]2=[N:32][CH:33]=[CH:34][CH:35]=[C:30]2[CH:29]=1)=O)C>>[CH3:47][C@H:37]1[N:36]2[C:28](=[CH:29][C:30]3[C:31]2=[N:32][CH:33]=[CH:34][CH:35]=3)[C:40](=[O:41])[NH:39][CH2:38]1

参加物

3

反応物 2

HCID 69556545(R)-1-(2-tert-Butoxycarbonylamino-1-methyl-ethyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ethyl esterHCID 86590113(4R,9aR)-6-bromo-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester

生成物 1

HCID 69556684(R)-4-Methyl-3,4-dihydro-2H-2,4a,5-triaza-fluoren-1-one

実験手順

This compound was prepared in analogy to Example 1 intermediate b), from (R)-1-(2-tert-butoxycarbonylamino-1-methyl-ethyl)-1H-pyrrolo [2,3-b]pyridine-2-carboxylic acid ethyl ester.

出典と根拠

ORDレコード
ord-ba91640e69894163ae5a9e5f20c566cd
出典データセット
uspto-grants-2006_08
特許番号
US07098337B2

関連ノート

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